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Gut microbes need something to eat, and when fiber is limited, they may begin consuming proteins from the mucus lining that protects the gut. Researchers found that fiber can suppress this process, while indigestible plant proteins help microbes produce more beneficial compounds.
Fossils collected in Osaka more than 30 years ago have revealed a surprise hiding in plain sight: four previously unrecognized bones from a giant Cretaceous mosasaur. Among them is the first confirmed premaxilla—the frontmost bone of the upper jaw—ever identified in a Japanese mosasaur fossil. Even more intriguing, parts of the skull show unusual anatomical features that don’t match known mosasaurs, raising the possibility that the remains belong to an entirely new species.
A widely available food-preservation chemical is emerging as a disturbing factor in rising UK suicide deaths, particularly among younger people and men. Researchers say the scale may be underestimated and are calling for urgent restrictions on access and harmful online information.
Scientists have uncovered why two seemingly opposite ways of targeting the same brain receptor can both promote weight loss. In mice, activating the GIP receptor in the brainstem reduced appetite, while blocking it in the hypothalamus removed a kind of “brake” on fullness signals. The discovery helps explain why very different obesity drugs can achieve similar results and suggests that carefully combining GIP-targeting treatments with GLP-1 drugs like those related to Wegovy and Ozempic could produce stronger effects.
Scientists have discovered that the aging human brain may be far less isolated from the rest of the body than once believed. Stanford researchers found that large numbers of immune cells from the blood begin entering the brain as early as middle age, where they can transform into microglia, the brain’s specialized immune cells. The finding overturns a long-standing assumption that these cells remain largely separate from the body’s immune system throughout life.
Nuclear reactors may go dark, but their fuel continues producing a faint antineutrino “glow” long after shutdown. Researchers have now detected that residual signal for the first time, finding it closely matched predictions of radioactive decay inside the reactor and nearby spent-fuel pools. The breakthrough suggests antineutrino detectors could eventually monitor reactors even when they are offline.
A tiny superconducting engine has successfully converted heat near absolute zero into useful work, demonstrating the first cyclic quantum heat engine of its kind. Future versions could operate autonomously inside quantum computers, potentially eliminating huge numbers of costly, noise-producing microwave cables.
Simply choosing the stairs could have surprisingly big benefits for your heart and longevity. A large analysis involving more than 480,000 people found that regular stair climbers were 39% less likely to die from cardiovascular disease and 24% less likely to die from any cause than people who rarely took the stairs. They also had lower risks of heart attack, stroke, and heart failure.
A surprising stress-related signal may help the brain repair itself after injury. Researchers found that myelin-producing precursor cells rapidly release the stress hormone CRH near damaged brain tissue, helping control how those cells mature and rebuild protective nerve insulation. The same system also influences brain development and the thickness of myelin later in life. The findings could offer new clues about how early-life stress contributes to psychiatric disorders.
Women who used estrogen-only hormone therapy later in life were less likely to develop dementia and showed fewer signs of Alzheimer’s disease in their brains, according to a large study of more than 21,000 participants. Hormone therapy use was linked to 39% lower odds of a dementia diagnosis and 35% lower odds of Alzheimer’s-related brain changes at autopsy, including amyloid plaques and tau tangles. Biomarker tests also suggested less amyloid buildup among hormone therapy users.
Scientists have found that the AMOC may be far more vulnerable to rapid warming than to temperature alone. When warming happens slowly, the ocean can adapt, but at faster rates similar to today’s, the massive Atlantic circulation could reach a tipping point at much lower temperatures.
A large study of more than 5,500 adults over 50 found a striking combination of risk factors: abdominal obesity paired with vitamin D deficiency was linked to a 123% higher risk of death over six years. Each condition was associated with increased risk on its own, but together they appeared to create a dangerous feedback loop, with belly fat reducing the amount of vitamin D available in the bloodstream while low vitamin D may worsen inflammation and other health problems.
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“GPT-5.5's API pricing is reshaping how startups build AI products”
